![]() ![]() ![]() Acidic hydrolysis of bromazepam studied by high performance liquid chromatography. Since the introduction of the first benzodiazepine, chlordiazepoxide, in 1960, more than 50 benzodiazepine drugs has been made available for the treatment of anxiety.īromazepam (C 14H 10BrN 3O), chemically known as 7-bromo-1, 3-dihydro-5(2-pyridyl)-2H-1, 4-benzodiazepin-2-one, is a member of the 1, 4-benzodiazepine drug that was first synthesized by Fryer, in 1964 [ 2 Panderi I, Archontaki H, Gikas E, Parissi-Poulou M. Benzodiazepines are among the most frequently used psychotropic drugs because of their efficiency, rapid effect and low toxicity. Anxiolytics are drugs used to relieve anxiety or prevent anxiety attack which is broadly defined as a state of unwarranted or inappropriate worry, often accompanied by restlessness, tension, destruction, irritability, and sleep disturbances [ 1 Sandford JJ, Argyropoulos SV, Nutt DJ.
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